Clinical progression of Alzheimer’s disease is characterized by impairment in cognition and function. The objective of the recent study published in the JPAD Journ Prevention Alzheiemr’s diseases is to assess the relationship between cognitive and functional impairment in mild Alzheimer’s disease. Correlation between cognitive and functional measures was 0.41 at baseline and 0.65 at Week 80. Autoregressive cross-lagged panel analysis demonstrated that cognitive impairment preceded and predicted subsequent functional decline, but functional scores did not predict cognitive outcomes. This study supports the hypothesis that functional impairment predictably follows cognitive decline in mild Alzheimer’s disease dementia.

Article H. Liu-Seifert